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ALS affects men more often than women, and Caucasian and non-Hispanic men are at a slightly higher risk. However, ALS does not discriminate: anyone could be at risk of developing the disease.

Experts estimate that between five and 10 percent of ALS cases are hereditary (classified as familial ALS).

When there is a hereditary element in ALS, only one parent needs to carry the gene for children to inherit it. However, the gene mutation doesn’t guarantee a grim prognosis — it may lead to ALS at some point, but also may not.

Around 90 percent of ALS cases are “sporadic” (they cannot be traced to any genetic risk), which can make it difficult to diagnose early. In these cases, family members of the patient are not at any increased risk of developing ALS.

Research on ALS has escalated in recent years (notably since the ALS Ice Bucket Challenge swept through the online community), and doctors have made gains in diagnosis and treatment. However, there is no cure for ALS; in order to slow down progression and preserve independence for longer, it’s important to find and treat the disease early.

Weakness. Loss of coordination. Spasticity.

As more voluntary muscles are affected, more drastic symptoms of nerve damage and muscle atrophy will develop: the arms and legs may become paralyzed, then the rest of the body, and eventually the deep muscles in charge of swallowing and breathing will fail. Tragically, most people with ALS die from respiratory failure within five years from the onset of symptoms.

ALS does spare some areas and processes. Intelligence and comprehension are usually not affected, and all the senses continue to operate as usual.

Most patients remain in control of their eye movements, bladder function, and bowel function. However, there is a possible link between late-stage ALS and dementia.

Diagnosing ALS means ruling out other diseases. The tests used (like X-rays, electromyography (EMG), and nerve conduction studies) seek to distinguish the specific nerve damage of ALS from other types of nerve damage.

MRI scans can help pick up underlying problems: while regular MRI scans won’t turn up evidence of ALS, they can reveal other conditions that could be causing the ALS-like symptoms, such as a herniated disk, a cyst in the spinal cord, or a tumor.

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https://insidegovuk.blog.gov.uk/2014/08/04/sentence-length-why-25-words-is-our-limit/

Posted by: Sara Vincent , Posted on: - Categories: Pearl iZUMi Womens W EM Trail N 2 Running Shoe Living Coral / Mandarin Red QiP3Q

We recently blogged about our checklist for reviewing content and got a lot of questions about sentence length.

The Service Design Manual explains how people read and why sentences longer than 25 words aren't accessible.

In the style guide we’re now saying that if you have sentences longer than 25 words, try to break them up or condense them. If you can’t, make sure they’re in plain English.

When you write more, peopleunderstand less

GOV.UK should be an authoritative, trusted source. This means we need to write in a way everybody understands. We know people distrust jargon and that being clear and direct helps - as do shorter sentences.

Writing guru Ann Wylie describes research showing that when average sentence length is 14 words, readers understand more than 90% of what they’re reading. At 43 words, comprehensiondrops to less than 10%.

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that sentences of 11 words are considered easy to read, while those of 21 words are fairly difficult. At 25 words, sentences become difficult, and 29 words or longer, very difficult.

People don’t read

Long sentences aren't just difficultfor people who struggle with reading or have a cognitive disability like dyslexia or attention deficit hyperactivity disorder. They're also a problemfor highly literate people with extensive vocabularies.

This is partly because Kenneth Cole New York Mens Hi Five Oxford Navy MevVpn
. In fact, most people only read around 25% of what’s on a page. This means it’s important to get information across quickly.

If it’s complex, make it simple

Long, complicated sentences force users to slow down and work harder to understand what they’re reading. This isn’t something people want to do, even if they’re familiar with the subject or language you’re using.

It’s easy to assume this isn’t the case for highly literate readers or people considered experts. Yet the more educated a person is, and the more specialist their knowledge, the more they want it in plain English .

These people often have the least time and most to read. Which means they just want to understand your point and move on, quickly.

Cut through the noise

It’s also important to think about how people access your content. They might be in a busy office, fighting for space on a crowded train or peering at their mobile in bed.

They don’t have time to deconstruct sentences and contemplate clauses, they just want you to get to the point.Doing thisshows you respect your reader’s time, interest and attention.

If you write short sentences using plain English, it’ll help more people understand your content. And by making it more accessible, you won’t just help your busiest readers, you’ll open it up to people who might otherwise struggle to understand it.

The information in this blogpost may now be out of date. See the current GOV.UK content and publishing guidance .

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